JVATiTD - Articles
Official publication of CEVAP/UNESP
Translational science at the undergraduate level: awakening talents to overcome the valley of death - case report
Rui Seabra Ferreira Jr.1,2, Cristina Kampus Mantovani1, Ana Silvia Sartori Barraviera Seabra Ferreira2, Laura de Oliveira Nascimento3, Merari de Fátima Ramires Ferrari4, Daniel Fabio Kawano3, Katlin Brauer Massirer5, Gabriel Forato Anhê6, Rosley Anholon3, Celso Pereira Caricati1, Luciane Meneguin Ortega4, Sarah Guilbert7, Teresa Lambe8, José Paes Oliveira-Filho9, Sue Ann Costa Clemens10, Benedito Barraviera1,2 [ + show more ]
Received: 03 February 2025 | Accepted: 09 April 2025 | Published online: 23 May 2025
https://doi.org/10.1590/1678-9199-JVATITD-2025-0005
Abstract
Background: In the biomedical field, translational science is the process of applying basic scientific knowledge to advance clinical research through the creation of new drugs, devices, medical procedures, preventive measures, and diagnostic kits. The Covid-19 pandemic exposed a shortage of professionals trained in translational research, essential for responding to global demands. To drive advancements, researchers must overcome the ‘valley of death’, a critical phase in clinical investigation. In response, CEVAP at São Paulo State University (UNESP), Botucatu, Brazil, has developed a strong 'knowledge industry' centered on Translational Science. As part of its research and innovation efforts, CEVAP has developed two biopharmaceuticals, the fibrin sealant and the apilic antivenom, which are currently in the final stage of development. In 2024, CEVAP began the first Brazilian Contract Development and Manufacturing Organization (CDMO) for developing and producing validated and qualified pilot-scale batches to generate clinical trial material. Case Presentation: The implementation of the optional undergraduate course in Translational Science marks a crucial step in strengthening the ‘knowledge industry’. The program, developed in collaboration with São Paulo’s three public universities (USP, UNESP, and UNICAMP), also involves an international partnership with the University of Oxford’s Department of Pediatrics and the Oxford Research Group LATAM. The successful launch of this course underscores its importance in interdisciplinary education and institutional collaboration. By bridging gaps between research and application, the program equips professionals to meet the growing demand for expertise in translational science. Given the project's success, it will transition into a one-year ‘Qualification in Translational Science’, available to students enrolled in São Paulo state universities. Conclusion: The preparation of these professionals will be strategic for transforming basic research into products for health, saving lives, and combating future pandemics that will emerge around the world.
Keywords: Translational science; Valley of death; Undergraduate course; CDMO.