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Molecular genetic association of rs8099917 and rs1800795 polymorphisms in the progression of hepatitis Delta virus liver disease

Ana Maísa Passos-Silva1,2,4,5*, Eugênia de Castro e Silva4, Lourdes Maria Pinheiro Borzacov4, Adrhyan Araújo1,4,5, Anita Sperandio Porto3,6, Juan Miguel Villalobos Salcedo3,4,5, Deusilene Vieira1,2,4,5 [ + show more ]

J Venom Anim Toxins incl Trop Dis, 2024, 30:e20230025
Received: 12 May 2023 | Accepted: 23 November 2023 | Published online: 12 January 2024
https://doi.org/10.1590/1678-9199-JVATITD-2023-0025

Abstract

Background: The relationship between viral infections and host factors holds high hopes for identifying the role of Interferon Lambda 3 (IFNL3) and Interleukin 6 (IL-6) polymorphisms in the development of Chronic Liver Disease (CLD) in patients infected with hepatitis Delta virus (HDV) in the Western Brazilian Amazon. Methods: Cross-sectional study conducted with a cohort of 40 chronic HDV patients, 27 with CLD and 13 without evident liver damage. Biological samples from the participants were analyzed using the polymerase chain reaction (PCR) technique, followed by sequencing by the automated Sanger method. Results: The rs8099917 T allele, from the IFNL3 gene, showed a higher frequency in both groups; however, it was not possible to establish an association with HDV infection [OR = 1.42 (0.42 – 4.75; p = 0.556 (95% CI). For IL-6, the rs1800795 G allele was superior to rs1800795 C. Analyzing both distributions in the studied groups, any association with HDV was absent (p > 0.05). Conclusion: The results suggest that the rs8099917 T/G (IFNL3) and rs1800795 G/C (IL-6) polymorphisms are not associated with the evolution of HDV in the studied population.

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